ABSTRACT
ABSTRACT Introduction: The results of the exercises provide an important parameter for evaluating the impact of aerobic activities on athletes. Cyclic training is believed to perform better due to its combination of functional movements. Objective: Study how cyclic training affects fitness in the performance of aerobic gymnastic movements in its practitioners. Methods: 90 athletes practicing aerobic gymnastics were selected, and randomly divided into experimental and control groups, for a 9-week experiment. While the control group practiced the daily exercises, the experimental group added a cyclic training protocol. Tests were performed before and after the intervention to measure any variation in the athletes' fitness. Results: The rate of ground weight lifting in one minute in the experimental group increased from 16.72±4.98 to 18.37±4.16, the number of lifts per minute was increased from 38.56±8.50 to 39.38±7.35, the number of rope jumps in one minute also increased from 149.90±14.67 to 158.30±11.52, and the gain in the exercise of vertical and horizontal supports in 30 seconds evolved from 16.96±2.21 to 17.33±2.42. The experimental group also achieved significant improvements after the circulation training. In contrast, the changes in the data of both groups in the control group were not as evident as those in the experimental group. Conclusion: The combination of cycling and daily training can effectively improve the functional performance of aerobic gymnasts. Level of evidence II; Therapeutic studies -investigation of treatment outcomes.
RESUMO Introdução: O resultado dos exercícios fornece um parâmetro importante para a avaliação do impacto das atividades aeróbicas sobre os atletas. Acredita-se que o treinamento cíclico possa desempenhar melhores resultados devido a sua combinação de movimentos funcionais. Objetivo: Estudar como o treinamento cíclico afeta aptidão física no desempenho dos movimentos da ginástica aeróbica em seus praticantes. Métodos: Foram selecionados 90 atletas praticantes de ginástica aeróbica, divididos aleatoriamente em grupo experimental e controle, para uma experiência com duração de 9 semanas. Enquanto o grupo de controle praticou os exercícios cotidianos, ao grupo experimental foi adicionado um protocolo de treinamento cíclico. Testes foram executados antes e após a intervenção para mensurar qualquer variação na aptidão física dos atletas. Resultados: O índice de levantamento de peso terra em um minuto no grupo experimental elevou-se de 16,72±4,98 para 18,37±4,16, a quantidade de levantamentos por minuto foi incrementada de 38,56±8,50 para 39,38±7,35, o número de saltos de corda em um minuto também se elevou de 149,90±14,67 para 158,30±11,52, e o ganho no exercício de apoios verticais e horizontais em 30 segundos evoluiu de 16,96±2,21 para 17,33±2,42. O grupo experimental também obteve melhoras significativas após o treinamento de circulação, enquanto as mudanças de dados dos dois grupos no grupo de controle não foram tão evidentes quanto as do grupo experimental. Conclusão: A combinação do treinamento cíclico ao treinamento diário pode efetivamente melhorar o desempenho funcional dos praticantes de ginástica aeróbica. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.
RESUMEN Introducción: El resultado de los ejercicios proporciona un parámetro importante para la evaluación del impacto de las actividades aeróbicas en los atletas. Se cree que el entrenamiento cíclico puede ofrecer mejores resultados debido a su combinación de movimientos funcionales. Objetivo: Estudiar cómo afecta el entrenamiento cíclico a la condición física en la realización de movimientos gimnásticos aeróbicos en sus practicantes. Métodos: Se seleccionaron 90 atletas practicantes de gimnasia aeróbica, divididos aleatoriamente en grupo experimental y grupo control, para un experimento de 9 semanas de duración. Mientras el grupo de control practicaba los ejercicios diarios, al grupo experimental se le añadió un protocolo de entrenamiento cíclico. Se realizaron pruebas antes y después de la intervención para medir cualquier variación en la forma física de los atletas. Resultados: El ritmo de levantamiento de peso en el suelo en un minuto en el grupo experimental aumentó de 16,72±4,98 a 18,37±4,16, la cantidad de levantamientos por minuto se incrementó de 38,56±8,50 a 39,38±7,35, el número de saltos de cuerda en un minuto también aumentó de 149,90±14,67 a 158,30±11,52, y la ganancia en el ejercicio de apoyos verticales y horizontales en 30 segundos evolucionó de 16,96±2,21 a 17,33±2,42. El grupo experimental también obtuvo mejoras significativas tras el entrenamiento circulatorio, mientras que los cambios en los datos de ambos grupos en el grupo de control no fueron tan evidentes como los del grupo experimental. Conclusión: La combinación del entrenamiento en bicicleta con el entrenamiento diario puede mejorar eficazmente el rendimiento funcional de los practicantes de gimnasia aeróbica. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.
ABSTRACT
Objective: Radiotherapy becomes more and more important in hepatocellular carcinoma (HCC) due to the development of technology, especially in unresectable cases. Metformin has a synergistic benefit with radiotherapy in some cancers, but remains unclear in HCC. This study aims to investigate the effect of metformin on radiosensitivity of HCC cells and the roles of specificity protein 1 (Sp1) as a target of metformin. Methods: The SMMC-7721 cell line was exposed to various doses of γ-ray irradiation (0, 2, 4, 6, and 8 Gy) and with or without different concentrations of metformin (0, 1, 5, 10, and 20 mM) to measure the radiosensitivity using MTT assay. Flow cytometry was used to determine cell cycle by propidium iodide (PI) staining and apoptosis by Hoechst 33342/PI staining and Annexin V-FITC/PI staining. Real-time polymerase chain reaction and Western blotting were performed to analyze the Sp1 mRNA and protein expressions of Sp1 and epithelial-to-mesenchymal transition (EMT) marker E-cadherin and Vimentin. The invasion capability was measured by the Boyden chamber assay. Results: In SMMC-7721 cells exposed to irradiation, metformin reduced proliferation and survival cells at various concentrations (0, 1, 5, 10, and 20 mM) and induced cell cycle arrest, apoptosis, and inhibited invasion. In SMMC-7721 cells with irradiation, the mRNA and protein expressions of Sp1 were significantly decreased by metformin as well as a selective Sp1 inhibitor. Metformin attenuated transforming growth factor-β1 induced decrease of E-cadherin and increase of Vimentin proteins. Conclusion: Metformin demonstrated enhanced radiosensitivity and inhibition of EMT in HCC cells. Sp1 might be a target of metformin in radiosensitization
ABSTRACT
Abstract@#From the perspective of healthy China, the promotion of adolescent health literacy should be transformed from pure medical health promotion to non-medical health intervention and biomedical intervention. Based on the background, train of thought, framework, process, this paper tries to construct the model of promoting adolescent health literacy. It is concluded that the promotion of adolescent health literacy is mainly organized and implemented by schools, communities and medical institutions, with the evaluation system of "3+6" health literacy as the main content, and the measures of promoting sports and medicine should be emphasized. Through the school health education, the community health service, the medical health service multiplex way enhances the youth health literacy level.
ABSTRACT
Patient-derived tumor xenograft(PDTX)models are based on the transfer of primary tumor tissue directly from the patient into immunodeficient mice.PDTX models retain many of the key characteristics of the original cancers,including heterogeneity,histo-logical characteristics,molecular diversities,and host microenvironments.These models do not only serve as platforms for co-clinical trials to determine precisely targeted therapies,but can also be applied to the development of biomarkers and action targets for drug responsiveness and personalized drug selection.PDTX models combined with clinical,genomic,and pharmacodynamic data and ap-plied to the individualized treatment of cancer patients could increase the specificity of drug use,improve clinical treatment success, and promote the development of individualized treatment and precise medical regimes.This review summarizes the historical back-ground,influential modeling factors,clinical applications,and limitations of PDTX mouse models.
ABSTRACT
The purpose of this study was to evaluate the clinical significance of visualized area percentage assessment of cleansing score [AAC] and computed assessment of cleansing score [CAC] of these two small bowel cleanliness scores systems for capsule endoscopy [CE]. The reliability and consistency of the AAC and CAC scores were evaluated by comparing the scores by two examiners [one expert, one without any training in CE]. Reliability was determined using the intraclass correlation coefficient [ICC] and consistency was determined using the kappa statistic. The inter-observer agreement was excellent for both the AAC and CAC scores. For AAC, the ICC was 0.791 [95% confidence interval: 0.677-0.868], and for CAC the ICC was 1.000. Using 1.5 as the cutoff, there was no significant difference between AAC and CAC results by the expert examiner [kappa 0.756, P 0.000] or the non-expert examiner [kappa 0.831, P 0.000]. Evaluation of small bowel cleanliness using AAC took 15-30 min, and evaluation using CAC took about 2-3 min. The overall adequacy assessment [OAA] using the AAC was not significantly different between the two examiners [chi[2] 0.586, P 0.444]. There were also no significant differences between the OAA using the AAC and the OAA using the CAC by the expert examiner [chi[2] 1.730, P 0.188] or the non-expert examiner [chi[2] 1.124, P 0.289]. Both of these scores for assessment of small bowel cleanliness can be useful in clinical practice, but the CAC is simpler to use